Mesenchymal stem cells and three‐dimensional‐osteoconductive scaffold regenerate calvarial bone in critical size defects in swine
نویسندگان
چکیده
منابع مشابه
Erratum: Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold
Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation potential; therefore, they are an attractive seeding source for tissue engineering therapy. Here we found that hMSCs with a scaffold did not affect cell v...
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autografts or autografts to prevent nonunion of bone defects. While successful in regenerating lost bone, there are problems with both donor site morbidity and availability. Current bone graft substitutes, such as collagen, have problems with immunogenicity and controlled delivery of the protein. Current alternatives to this involve the delivery of recombinant Bone Morphogenetic Protein 2 (BMP-...
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Bone tissue engineering technique is a promising strategy to repair large-volume bone defects. In this study, we developed a 3-dimensional construct by combining icariin (a small-molecule Chinese medicine), allogeneic bone marrow-derived mesenchymal stem cells (BMSCs), and a siliceous mesostructured cellular foams-poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (SMC-PHBHHx) composite scaffold. We...
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Postnatal tissue-specific stem/progenitor cells hold great promise to enhance repair of damaged tissues. Many of these cells are retrieved from bone marrow or adipose tissue via invasive procedures. Peripheral blood is an ideal alternative source for the stem/progenitor cells because of its ease of retrieval. We present a coculture system that routinely produces a group of cells from adult peri...
متن کاملEffects of mesenchymal stem cells in critical size bone defect.
BACKGROUND AND OBJECTIVES The aim of this study was to compare culture-expanded, bone marrow-derived mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) loaded to biphasic calcium phosphate (BCP) bone ceramic in the repair of rat calvarial bone. MATERIALS AND METHODS Critical-size (7 mm dia.) calvarial defects were prepared in the frontal-parietal bones of 90 adult female Sprague-Daw...
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ژورنال
عنوان ژورنال: STEM CELLS Translational Medicine
سال: 2021
ISSN: 2157-6564,2157-6580
DOI: 10.1002/sctm.20-0534